ssr码分享2019

RUP response to COVID-19 crisis

ssr码分享2019
ssr码分享2019
ssr码分享2019
ssr码分享2019
ssr码分享2019

JEM staff members are working remotely in line with New York City’s efforts to contain COVID-19. While our offices are physically closed, editorial and publication operations continue. JEM staff can be reached via email and phone, as we tend to our family, friends and community. Thank you for your patience and understanding.

Newest Articles

Article

| July 31 2020

GATA2-regulated developmental trajectories

Kirby D. Johnson, Daniel J. Conn, Evgenia Shishkova, Koichi R. Katsumura, Peng Liu, Siqi Shen, Erik A. Ranheim, Sean G. Kraus, Weixin Wang, Katherine R. Calvo, Amy P. Hsu, Steven M. Holland, Joshua J. Coon, Sunduz Keles, Emery H. Bresnick

By elevating levels of the GATA2 transcription factor in hematopoietic progenitor cells, a transcriptional enhancer establishes multilineage differentiation potential. During embryogenesis, deleting the enhancer upregulates innate immune machinery and deconstructs multilineage potential to favor monocytic differentiation.

Article

| July 29 2020

The existence of a circulating CD8 + T RM precursor

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Following local inflammation, CD8+ T cells develop into tissue-resident memory T cells (TRM). Through combined lineage tracing and single-cell transcriptome analysis, the authors show that the circulating T cell pool harbors TRM precursors that commit to the TRM fate before tissue entry.

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Brief Definitive Report

| July 29 2020

Aberrant AKT activation drives ganglioneuroma

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Brief Definitive Report

| July 28 2020

A defect in STING trafficking causes COPA syndrome

Zimu Deng, Zhenlu Chong, Christopher S. Law, Kojiro Mukai, Frances O. Ho, Tereza Martinu, Bradley J. Backes, Walter L. Eckalbar, Tomohiko Taguchi, Anthony K. Shum

A defect in COPI transport due to mutant COPA causes multimerization of STING on the Golgi and type I interferon–driven immune dysregulation in mice. Small-molecule inhibition of STING activation is a new molecular target for treating COPA syndrome.

Brief Definitive Report

| July 28 2020

Plasma p-tau isoforms’ utility for AD diagnosis

Nicolas R. Barthélemy, Kanta Horie, Chihiro Sato, Randall J. Bateman

萌娘学院中文破解版下载-萌娘学院(附攻略以及福利)最新破解 ...:今天 · 萌娘学院破解版是一款非常有趣的二次元养成类的手游，萌娘学院破解版的游戏中采用精美的游戏画面以及可爱生动的人物形象，日系风格的画风也会吸引更多的玩家。另外简单的游戏操作，亲密的互动玩法也会让玩家血脉喷张！宅男们的福音哦！

| July 28 2020

COPA regulates interferon signaling through STING

Alice Lepelley, Maria José Martin-Niclós, Melvin Le Bihan, Joseph A. Marsh, Carolina Uggenti, Gillian I. Rice, Vincent Bondet, Darragh Duffy, Jonny Hertzog, Jan Rehwinkel, Serge Amselem, Siham Boulisfane-El Khalifi, Mary Brennan, Edwin Carter, Lucienne Chatenoud, Stéphanie Chhun, Aurore Coulomb l’Hermine, Marine Depp, Marie Legendre, Karen J. Mackenzie, Jonathan Marey, Catherine McDougall, Kathryn J. McKenzie, Thierry Jo Molina, Bénédicte Neven, Luis Seabra, Caroline Thumerelle, Marie Wislez, Nadia Nathan, Nicolas Manel, Yanick J. Crow, Marie-Louise Frémond

Heterozygous missense mutations in COPA underlie constitutive interferon signaling through STING, thereby defining a novel type I interferonopathy and emphasizing the importance of the ER–Golgi axis in interferon homeostasis. Based on these results, three patients have been treated with interferon signaling (JAK1) inhibitors.

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Article

| July 27 2020

Proteome-wide profiling of HPV-specific T cell immunity

SSR破解版怎么下载破解版下载安装教程_SSR_九游手机游戏:2021-1-3 · 手机搜索【SSR破解版九游】玩家可以打开手机进行搜索【SSR九游】就会展示对应的下载专区，这里会有两个下载选框【高速下载】【普通下载】，小编在这里建议大家使用高速下载，这样可以节省 80% 的下载时间，让你快速体验到游戏给你带来的不一样乐趣。

Proteome-wide profiling of HPV-specific T cell immunity in oropharyngeal cancer (OPC) patients reveals broad and multiple antigen-specific reactivities directed to HPV-encoded proteins E1, E2, E4, E5 E6, E7, and L1. These observations provide novel insights for future development of cellular immunotherapies for HPV-associated OPC patients.

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